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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It's called Zofran (generic name is ondansetron). Zofran is used in the treatment of nausea/vomiting; nausea/vomiting, chemotherapy induced; nausea/vomiting, postoperative; nausea/vomiting, radiation induced and. Zofran, which was approved in 1989, was designed to counter the nausea and vomiting from chemotherapy, and has revolutionized the entire process, allowing patients many of whom stopped their therapy early because of the side effects to finish chemo, and possibly save their lives.. Zofran is not for preventing nausea or vomiting. To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. 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